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Biomedical Sciences (BMS)

Department Chairperson

David M. Ojcius
Professor of Biomedical Sciences


A

Leigh Charles Anderson
Professor of Biomedical Sciences
BS, University of Minnesota, 1971
DDS, University of Minnesota, 1977
PhD, University of Minnesota, Oral Biology, 1979

Homayon Asadi
Associate Professor of Biomedical Sciences
B.A., San Jose State University, Biology, 1984
D.D.S., University of the Pacific, 1988
San Jose City College, 1982

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B

Alan Wythe Budenz
Professor of Biomedical Sciences
University of Redlands, 1970
BS, Oregon State University, Zoology, 1972
MS, University of California, Los Angeles, Anatomy, 1977
DDS, University of California, San Francisco, Dentistry, 1982
MBA, Univesity of the Pacific, Business, 2000

Dorothy T. Burk
Associate Professor of Biomedical Sciences
BA, University of New Hampshire, Zoology, 1972
MA, University of the Pacific, Educational Counseling Psychology, 1994
PhD, University of Michigan, Anatomy, 1976
University of Virginia, Craniofacial Development, 1979

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C

Takahiro Chino
Assistant Professor of Biomedical Sciences
DDS, Japanese Ministry of Public Health, Dentistry, 1991
DDS, Matsumoto Dental University, Dentistry, 1991
Indiana University School of Dentistry, Oral Surgery, Medicine Pathology, 1995
Matsumoto Dental University, Japan, Oral Maxillofacial Surgery, 1993
MSD, Indiana University School of Dentistry, Dental Diagnostic Sciences, 1999
Other, Indiana University School of Dentistry, Oral Diagnosis, 1996
PhD, University of Washington, Oral Biology, 2008
University of Medicine Dentistry of New Jersey, Postdoctural Fellow, Periodontics, 2010

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D

Nejat A. Duzgunes
Professor of Biomedical Sciences
BS, Middle East Technical University, Ankara, Turkey, Physics, 1972
Diploma, Noble and Grenough School, Deham, Mass., 1968
Other, University of California, San Francisco, Membrane Biophysics, 1981
PhD, State University of New York at Buffalo, Biophysical Sciences, 1978

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H

Stefan Highsmith
Professor of Biomedical Sciences
BA, University of California, Berkeley, Chemistry, 1966
Brandeis University, Physical Chemistry, 1974
PhD, Massachusetts Institute of Technology, Organic Chemistry, 1972
University of California, San Francisco, Biophysical Chemistry, 1978

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M

Ana Carolina Morandini
Assistant Professor of Biomedical Sciences
DDS, University of Sao Paulo, Bauru, School of Dentistry, 2006
MS, University of Sao Paulo Bauru, Periodontology, 2009
PhD, University of São Paulo, Bauru School of Dentistry, PhD in Oral Biology, 2016

Alexander J. Murphy
Professor of Biomedical Sciences
BS, Brooklyn College, Chemistry, 1962
PhD, Yale University, Biochemistry, 1967
University of California, San Francisco, Biophysical Chemistry, 1970

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O

David M. Ojcius
Professor of Biomedical Sciences
BS, University of California, Berkeley, Biophysics, 1979
Harvard Medical School, Postdoctoral Fellow, 1987
PhD, University of California, Berkeley, Biophysics, 1986
Rockefeller University, New York, Postdoctoral Fellow, 1991

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R

Gary D. Richards
Associate Professor of Biomedical Sciences
A.A., Chabot College, 1977
B.A., University of California at Berkeley, Anthropology, 1980
M.A., University of California at Berkeley, Anthropology, 1984
PhD, University of California at Berkeley, Anthropology, 2007

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T

Der Thor
Assistant Professor of Biomedical Sciences
BS, University of the Pacific, Biological Sciences, 2000
MS, University of the Pacific, Biological Sciences, 2003
PhD, University of the Pacific, Physiology and Pharmacology, 2009

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X

Nan Xiao
Assistant Professor of Biomedical Sciences
BS, Peking University, Stomatology, 2003
MS, Peking University - School of Stomatology, Orthodontics, 2005
PhD, Hong Kong University of Science and Technology, Biochemistry, 2009

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Z

Benjamin D. Zeitlin
Associate Professor of Biomedical Sciences
BSc, University of Strathclyde, Immunology and Pharmacology, 1992
PhD, Sheffield Hallam University, Immunopharmacology, 2000

D

Dorothy E. Dechant
Adjunct Assistant Professor of Biomedical Sciences
BA, University of California, Berkeley, Anthropology, 1973
MA, University of California, Berkeley, Anthropology, 1978
PhD, University of California, Berkeley, Anthropology, 1982

Alan J. Detton
Adjunct Assistant Professor of Biomedical Sciences
BS, Brigham Young University, Exercise Science, 2006
MS, Ohio State University, Biomedical Informatics, 2010
PhD, Ohio State University, Philosophy, 2012

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H

Robert Halliwell
Adjunct Professor of Biomedical Sciences
BS, University of Stirling, Biology and Psychology, 1983
MS, University of London, Neurological Science, 1985
PhD, University of Dundee, Clinical Pharmacology, 1992
University of California Irvine, Neuroscience, 1999

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K

Krystyna Konopka
Adjunct Professor of Biomedical Sciences
High School, Lodz, Poland, 1954
MD, School of Medicine, Lodz, Poland, Medicine, 1961
Bieganski Hospital, Lodz Poland, Clinical Pathology, 1965
Jonscher Hospital, Lodz Poland, Rotating Internship, 1965
MS, University of Lodz, Biochemistry, 1966
PhD, University of Lodz, Biochemistry, 1969

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M

Jesse Manton
Adjunct Instructor of Biomedical Sciences
BS, Sacramento State University, Business Management and General Administration, 2008
Sonoma State, Biochemistry, 2011
DDS, University of the Pacific, Arthur A.Dugoni School of Dentistry, General Dentistry, 2014
Other, VA Palo Alto Stanford Medical Center, Dentistry, 2015

Matthew Milnes
Adjunct Instructor of Biomedical Sciences
BS, California Lutheran University, Biology, 1997
MS, University of the Pacific, Biology, 2000
DDS, University of the Pacific School of Dentistry, General Dentistry, 2003

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P

Brigitte Papahadjopoulos-Sternberg
Adjunct Assistant Professor of Biomedical Sciences
BS, Karl-Marx-University Humboldt University Berlin, Chemistry, 1971
PhD, Humboldt-University, Berlin, 1976

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T

Scott P. Turner
Adjunct Instructor of Biomedical Sciences
University of California, Berkeley
A.B., Columbia University, Anthropology, 1994
M.A., University of California, Berkeley, Anthropology, 1997

Course Descriptions

Predoctoral Courses

AN 110. Human Anatomy I: Cells to Systems. 6 Units.

The student will gain an understanding of cell biology, functional histology, and gross anatomy of the human body as appropriate for professional health care providers. Emphasis will be on the integration of anatomical knowledge at all levels and its correlation with basic clinical medicine relevant to dentistry. (45 hours lecture, 40 hours laboratory, including 15 hours clinical correlations/case discussion. Quarters 1-2.).

AN 111. Human Anatomy II: The Orofacial Complex. 7 Units.

The student will gain an understanding of the embryology, histology, neuroanatomy and gross anatomy of the head and neck as appropriate for a dental professional. The objectives are for the student to (1) understand the normal development and structure of tissues of the head and neck in preparation for courses in oral pathology and oral medicine and (2) comprehend the biological basis for rational diagnosis and treatment of clinical problems. Emphasis will be on the integration of anatomical knowledge and its correlation with oral medicine and clinical dentistry (40 hours lecture, 40 hours laboratory, 20 hours seminar/case discussion, Quarter 3).

BC 114. Biochemistry. 6 Units.

Study of major molecular structures and processes of the human organism including structure, function, and biosynthesis of the informational macromolecules, proteins and nucleic acids; generation and storage of metabolic energy; structure, genesis, and transformations of mineralized tissues; and digestion, absorption, and utilization of required nutrients. (60 hours lecture, including 10 hours case-based discussion. Quarters 1-2.).

BMS 100. Integrated Medical Sciences. 0 Units.

MC 224. Microbiology. 6 Units.

The biology of microorganisms that cause disease, including caries, and periodontal and endodontic infections. Microbial structure, metabolism, genetics, and virulence factors; molecular diagnostics and recombinant DNA technology. Pathogenesis, epidemiology, clinical syndromes, laboratory diagnosis, treatment, and prevention of infectious diseases. Innate, humoral and cell-mediated immunity, hypersensitivity and vaccines. Antibacterial, antiviral and antifungal agents. Bacterial infections, including oral manifestations; oral microbiology. Virology, with emphasis on HIV, herpesviruses, and hepatitis viruses; oral manifestations of viral infections. Mycology, with emphasis on oral infections. Parasitology, with emphasis on global public health. Oral microbiology laboratory, including disinfectant and antibiotic susceptibility; the caries risk test and identification of oral bacteria. (57 lecture hours, including independent study hours; 15 laboratory hours. Quarters 4-5.).

PG 120. Physiology. 7 Units.

Study of the functioning of the human body, basic methods used to evaluate physiological parameters and introduction to recognition of functional abnormalities in humans. Cell membrane transport; electrical potentials; peripheral nerves; skeletal and smooth muscles; spinal cord and autonomic nervous system; circulatory system and respiratory system; homeostatic function of the kidneys; energy metabolism, temperature regulation, assimilation of food by the gastrointestinal tract; regulatory function of the endocrine system; perception of the external world through the sense organs, and integrative activity of the brain. (70 hours lecture and demonstrations including 10 hours case-based discussion. Quarters 1-3.).

PG 220. Pharmacology and Therapeutics. 6 Units.

Rationale of drug use in dental practice, and mechanisms of action of drugs used for the medical management of dental patients; pharmacodynamics and drug kinetics; quantitative pharmacology; drug laws and regulations; prescription writing; emergency drugs, autonomic, respiratory, cardiovascular, psychotropic, hormonal, gastrointestinal, antianxiety, antiparkinson, antidiabetic, antineoplastic drugs; neuromuscular blockers, histamine antagonists, inflammatory mediators, sedative- hypnotics, anticonvulsants, general and local anesthetics, analgesics, antibiotics, antifungal and antiviral agents, substance abuse, toxicology, drug interactions, and therapeutic decision making. (60 hours lecture. Quarters 6-8.).

Graduate Courses

AN 410. Advanced Head and Neck Anatomy I. 1 Unit.

This course presents head and neck anatomy in depth to provide residents essential foundation for dental procedures. The development of normal and pathological craniofacial shapes, as well as anatomical structures relevant for implant placement, are discussed in detail. (Quarter 1.).

AN 510. Advanced Head & Neck Anatomy II. 1 Unit.

This course covers head and neck anatomy in depth to provide residents with essential foundation knowledge for dental procedures. The development of normal and pathological craniofacial shapes, as well as anatomical structures relevant for implant placement, are covered in detail. (Quarter 5.).

BC 414. Biochemistry and Bioengineering I. 1 Unit.

Residents learn how to assess biocompatibility and longevity of various materials in contact with body fluid and tissues. This course also covers biofilm formation and removal from oral biomaterials. (Quarter 2.).

BMS 401. Research Philosophy and Design I. 1 Unit.

In this two-quarter foundational course, students learn about hypothesis-driven research, including hypothesis development and significance testing. (Quarter 1.).

BMS 411. Stem Cell Biology I. 1 Unit.

In this two-quarter course, residents discuss in detail current research on cell populations, their properties, and possible application routes--the foundation of modern biology-driven endodontic therapy. Treatment possibilities for immature teeth and other applications in regenerative endodontics are presented. (Quarter 2.).

BMS 412. Topics in Oral Biology I. 1 Unit.

This course covers the interaction of pulpal and periapical tissues with medicaments such as bisphosphonates or TNF-alpha blocking antibodies, the effects of systemic diseases such as HIV, diabetes or sclerodermia on oral tissues, and other common issues in endodontics. (Quarter 4.).

BMS 414. Oral Biology Journal Club I. 3 Units.

This course features discussion of papers on a variety of topics in oral biology.(Quarter 2.).

BMS 440. Thesis Protocol. 1 Unit.

In this independent-study research course, residents work with mentor(s) to develop research questions, formulate hypotheses, and write a formal research proposal that includes a full literature review, statement of material and methods, execution of the research, and appropriate analysis and interpretation of data. (Quarters 2-3.).

BMS 450. Research Project I. 3 Units.

In this independent-study research course, residents work with research mentors to perform the research project, including data gathering, complilation, and interpretation of the results. The course will culminate in a publishable manuscript.(Quarters 1-4.).

BMS 501. Research Philosophy and Design II. 1 Unit.

In this two-quarter foundational course, residents learn about hypothesis-driven research, including hypothesis development and significance testing. (Quarter 5.).

BMS 512. Topics in Oral Biology II. 1 Unit.

This course covers the interaction of pulpal and periapical tissues with medicaments such as bisphosphonates or TNF-alpha blocking antibodies, the effects of systemic diseases such as HIV, diabetes or sclerodermia on oral tissues, and other common issues in endodontics. (Quarter 8.).

BMS 514. Oral Biology Journal Club II. 3 Units.

Residents read and discuss current literature on a range of oral biology topics. (Quarter 6.).

BMS 550. Research Project II. 3 Units.

In this independent-study research course, residents work with research mentors to perform the research project, including data gathering, complilation, and interpretation of the results. The course will culminate in a publishable manuscript. (Quarters 5-8.).

BMS 651. Manuscript Preparation. 3 Units.

Residents prepare the final version of a publishable manuscript. (Quarter 9.).

MC 404. Host Response I. 1 Unit.

This course extends basic immunology to the etiology of pulpal and periapical disease focusing on the host response. The role of inflammatory mediators and the cells that elaborate them is discussed. (Quarter 1.).

MC 424. Oral Microbiology I. 1 Unit.

Residents learn about microbial structure, metabolism, genetics, and virulence factors; molecular diagnostics and recombinant DNA technology; pathogenesis, epidemiology, clinical syndromes, laboratory diagnosis, treatment, and prevention of infectious diseases. (Quarter 2.).

MC 504. Host Response II. 1 Unit.

This course extends from basic immunology to the etiology of pulpal and periapical disease focusing on the host response. The role of inflammatory mediators and the cells that elaborate them will be discussed. (Quarter 5.).

PG 420. Advanced Pharmacology I. 1 Unit.

Local anesthesia and pain management of acute and chronic pain are main components of this lecture series, with specific emphasis on endodontics. Infection control, including biochemistry and side effects, is also presented. (Quarter 1.).

PG 520. Advanced Pharmacology II. 1 Unit.

Local anesthesia and pain management of acute and chronic pain are two main components of this lecture series, with specific emphasis on endodontics. Infection control, including biochemistry and side effects, is also presented. (Quarter 5.).